Why A Pediatrician Won’t Prescribe This “Natural” Treatment

I met Dr. Mike Ginsberg via interweb first when we were both ranting about… the usual, the anti-science movement and the effect it has on his job. He was well spoken, passionate, and about as mad as I was about the fact that we had an outbreak of a disease that we thought we got rid of thirty years ago.

So when I was in San Francisco a few weeks ago, I caught up with Dr. Ginsberg over pizza and a diet coke or three.


Along with him being a great guy, speaking with someone who’s so knowledgeable about their field was wonderful. I was so inspired after our conversation that I even decided to do some research into public health degrees at the University of Arizona. I have always wanted to learn more about healthcare and my chat with the doctor really got me thinking. As much as I can answer questions about what is (and what isn’t) good science, it’s important to defer to experts like him on questions about medications for children. I’m not an expert in that field and I want people to get information from the right source. He started telling me (1) that a lot of medications are not recommended for children under a certain age and (2) about the research on the available medications in treating cough for infants… and the research indicates that placebos work as well as the stuff on the shelves.

And he’s not having it.

I asked him if he could write up his explanation, and here the good doc is in his own words.

Placebo for treating cough in children: why I won’t do it.
Mike Ginsberg, M.D., M.S., FAAP

An acute cough is defined as a cough lasting less than 15 days. Cough is the third-most common reason that patients see a doctor and the most common acute complaint to primary care physician’s offices.(1) As a practicing pediatrician, I’d estimate that visits for acute cough probably consume roughly a quarter of my average daily schedule between the months of December and March. The vast majority of acute cough in children is caused by self-limited viral upper respiratory infections (URI).(2) While some otherwise healthy children may have as many as 15 URIs in a year, the average child has a URI 5-6 times per year, which means that normal children between 6mo and 2yo will be sick at least once per month during the winter.(3)

Cough makes parents worry, it fills my schedule, and it makes me feel like a broken record. I walk into the room to see a smiling, drooling, happy baby with a light cough and a mother who has terror in her eyes worrying that “my mother said he might have pneumonia.” True pneumonia is vastly overdiagnosed by emergency rooms, urgent care centers, and primary care physicians. It actually only affects 5% of children in industrialized nations per year.(4) Of course, it’s our job as clinicians to recognize those rare cases of cough that are “more than just a cough.” But for acute cough, our job is to provide peace of mind. Peace of mind doesn’t need to take the form of a teaspoon of medicine. That’s why machines will never replace us and that’s what makes me get out of bed and go to work every morning.

Parents often reach for cough suppressants and decongestants but these medicines cause more harm than good in children under 5; they do not relieve symptoms, yet side-effects from overdoses are common.(5,6,7,8) One trial showed that “VapoRub” and that parents thought it was more effective than fragrance-free patrolatum or no treatment, but it will be hard to convince me that “VapoRub” is effective given that there’s no good way to make a placebo.(9) At least two randomized placebo-controlled trials found that a teaspoon of honey may be effective for relieving acute cough in children over 12 months although they don’t alter the outcome of the illness, and this is certainly a safe option that I confidently recommend to my patients.(10,11) Another study (partially funded by the Israeli Honey Board, but with sound methodology) found that three different types of honey all were equally effective for acute cough and more effective than a date nectar placebo.(12) This is fine for children over 12 months, **but in children under 12 months, honey is a risk for botulism poisoning and it is not safe to use.**(13)

As a pediatrician, that leaves me in a bit of a bind. Cough is a common and bothersome complaint in children under 12 months and I understand how desperate parents can be for something, anything to make it better. Furthermore, I worry that parents might ignore my advice to “just wait it out” and reach for these medications, anyway.

Enter Dr. Ian Paul ,Ms. Jessica Beiler, MPH, and friends (I’ve already cited two other papers of theirs here) with an article published in JAMA Pediatrics from November 2014 suggesting that placebo is effective in improving cough in children.(14)

Wait, what?

Actually, this is no big shock at all if you do what I do for a living. In their study, they took children 2-47 months old presenting to the office with a complaint of acute cough and randomized them into three groups. In one group, parents were educated that there was nothing that they could do and sent home. In the next group, parents were given a placebo of artificially-sweetened grape-flavored water. In the third group they were given agave nectar. The two groups that were given a product were told give a dose to their children that night and then were assessed for their perception of improvement.

Not surprisingly, parents of children who were given either placebo or agave nectar reported a significant improvement in the child’s symptoms and in the child’s and parents’ quality of sleep (some people claim though to have a better night’s sleep when they get the right mattress. If this is something which you can agree with then it might be a good idea to check out these mattress sizes). Well, no duh. Placebo is commonly known to be very effective for all sorts of physical complaints, which is exactly why any well-done study has a placebo control! The act of giving a child medicine is comforting for parents (and probably for the child) and makes them feel like they are doing something about it and thus, they report improvement in the cough.

The authors concluded: “In a comparison of agave nectar, placebo, and no treatment, a placebo effect was demonstrated, with no additional benefit offered by agave nectar. Health care professionals should consider the potential benefits and costs when recommending a treatment with only a placebo effect for infants and toddlers with nonspecific acute cough.”

Now, some colleagues who I respect a lot have started recommending agave nectar to parents of children 2-12 months with acute cough based on this data. Their reasoning is that it might stop parents from reaching for dangerous stuff like dextromethorphan or codeine and that it at least “helps” by allowing the parents to sleep soundly in the knowledge that they “did something to help the baby feel better.” The authors of this study are good researchers who have a knack for robust study design and they draw substantiated conclusions from their studies. They like the idea of offering a placebo, but I respectfully disagree.

I can’t bring myself to recommend it. Here’s why:

First of all, the folks at Zarbee’s are all over it, bless their hearts, selling 60mL (2 fl oz.) of grape-flavored dilute “all natural” agave nectar “cough syrup” for $7 on Amazon and I’ve seen $10+ in retail pharmacies. Many of my patients are poor. Zarbee’s frequently succeeds in getting them to spend that kind of money for some sugar water. I think it’s outrageous and I’m not playing along. Zarbee’s also sells a honey product that consists of diluted dark honey with some ivy leaf extract and a few other harmless things for the same price for 4oz for children 12mo and up. But as far as I know, nobody has ever done a double-blinded trial on it and there’s no evidence that it’s any better than straight honey, which is way cheaper.

Perhaps the strength of the placebo effect is improved the more you overcharge for it.(15)

Second, even for my well-to-do, six-figure income families, I still can’t bring myself to do it. Prescribing a placebo and even implying that it might actually help would involve misleading my patients and that’s not a line I’m willing to cross, even as innocuously as this one.

Third, while I’m willing to recommend honey for children over 12 months because it’s actually demonstrated to be more effective than placebo, remember that we have already established that acute cough is incredibly common in young children. Given that a typical acute cough can last up to two weeks (by definition), some otherwise healthy children may have acute cough for more days during a given winter than not. So much so that personally, I think of acute URI/cough as a variation of the normal physiologic state in children under 5 during winter. To me, in recommending a placebo for a baby with an acute cough that might hit as often as every two weeks, I am simply reinforcing the idea that this normal physiological state of affairs requires medication when it absolutely does not. I am a medical minimalist; I like to keep children away from “medications” –whether proven effective or not, whether “natural” or synthetic– unless absolutely necessary.

Finally, there are 3-6 grams of sugar in a “dose” of agave nectar,(16) and as we established, some kids may actually have acute cough for >50% of the days during a given winter, so that adds up to an awful lot of sugar. I’m not going to post references here (that’s a whole separate article) but trust me when I say that concentrated sugar is not good for us. Primum non nocere. “First, do no harm.”

For acute cough in infants aged 60 days to their first birthday, the best and most “natural” thing to do is nothing. I can’t recommend “VapoRub” without better evidence that it’s effective (although at least I can tell parents that it’s not unsafe to use). I can’t recommend agave nectar even leaving aside the outrageous price. The safest, most effective, and natural thing you can do for acute cough in an infant is to reassure yourself that this, too, shall pass and treat it with what we in the business call “tincture of time.”

-MLG June 2015

DISCLOSURE: The opinions expressed in this work are mine alone and not those of my employer or any other individual and organizations. I have no relationships, personal or financial, with any individual or organization referenced in this work.

So there’s the good doc’s word on cough medications. I’ll definitely trust the doctor who seeks evidence before prescribing and isn’t trying to make you spend money on unnecessary meds. Please stick to medications that are proven to help your children.

Like vaccines.


(1)http://www.cdc.gov/…/namcs_summary/2010_namcs_web_tables.pdf(Table 9)
(2)McCormick A, Fleming D, Charlton J. Morbidity statistics from general practice—fourth National Morbidity Survey, 1991–92. London, UK: HMSO, Office for National Statistics; 1995.
(3)Chonmaitree T, Revai K, et. al. Viral Upper Respiratory Tract Infection and Otitis Media Complication in Young Children. Infect Dis. 2008; 46(6):815-823.
(4) Rudan I, Boschi-Pinto C. Epidemiology and etiology of childhood pneumonia. Bull World Health Organ. May. 2008; 85(5) Abstract.
(5)Hutton N, Wilson NH, et al. Effectiveness of an Antihistamine-Decongestant for Young Children With the Common Cold: A Randomized Controlled Clinical Trial. J. Pediatrics 1991;118:125-130
(6)Taylor JA, Novak AH, et al. Efficacy of Cough Suppressants In Treating Nighttime Cough in Children. AJDC 1991; 145-389. Abstract.
(7)Gadomski A, Horton L, et al. The Need for Rational Therapeutics in the Use of Cough and Cold Medicine in Infants. Pediatrics 1992; 89(4)774 -776
(8)Infant deaths associated with cough and cold medications–two states, 2005. MMWR Morb Mortal Wkly Rep. 2007 Jan 12;56(1):1-4.
(9)Paul IM, Bieler JS, Vapor Rub, Petrolatum, and No Treatment for Children With Nocturnal Cough and Cold Symptoms. Pediatrics 2010;126:6
(10)Paul IM, Beiler J, et al. Effect of Honey, Dextromethorphan, and NoTtreatment on Nocturnal Cough and Sleep Quality for Coughing Children and Their Parents. Arch Pediatr Adolesc Med. 2007;161(12):1140–6.
(11)Olabisi O, Meremikwu MM, Honey for acute cough in children. Cochrane Acute Respiratory Infections Group. Published Online: 23 DEC 2014. Abstract
(12)Cohen HA, Rosen J, et al. Effect of Honey on Nocturnal Cough and Sleep Quality: A Double-blind, Randomized, Placebo-Controlled Study. Pediatrics 2012; 130(3)
(13)Cox N., Hinkle R. Infant Botulism. Am Fam Physician. 2002 Apr1; 65(7): 1388-1393. Review.
(14)Paul IM, Bieler JS. et al. Placebo Effect in the Treatment of Acute Cough in Infants and Toddlers: A Randomized Clinical Trial. JAMA Pediatr. 2014;168(12):1107-1113.

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About SciBabe 79 Articles
Yvette d'Entremont, aka SciBabe, is a chemist and writer living in Los Angeles with her husband and their four pets. She bakes a mean gluten free chocolate chip cookie and likes glitter more than is considered healthy for a woman past the age of seven.


  1. Thanks for this, it is hard as a parent when your child is coughing you are desperate for something to help, but I’d never considered the wider ramifications of choosing these placebos dressed as medicine.

  2. Nice article. I agree…unfortunately some in my profession (Pharmacy) have taken to selling snake oils such as dilute honey rather than serving their patients and the public….all for a few dollars of profit.

    One additional comment….raw honey can be dangerous to children less than 12 months – just a clarifying statement as you only recommended it for those >12months.

  3. Another drawback to giving sugar (in any of the various forms discussed) to children who are already sick is that it fosters thrush, a yeast infection typically resulting in white lesions on the tongue and throat. Babies are especially susceptible to thrush infection, which can cause irritation–and sometimes bleeding–for several weeks at a time. Ironically, the worst time to give a child the sugar is at bedtime (or naptime)–which, of course, is when a parent would be most likely to try to calm their child’s cough–because the sugar just sits in the throat, feeding the thrush.

  4. Thank you for more reassurance. I am a wait and see type when it comes to coughs and colds. All 3 of the Dr.s I’ve had since the birth of my 1st child have also been of that thinking. Although one of my daughters seems to develop breathing difficulties during a coughing episode it usually only happens once a year. We have a nebulizer on hand for such emergencies and one treatment is usually all that is needed. Medicines are used sparingly as needed. I believe my kids to be healthier for it.

  5. Considering my son went undiagnosed with asthma for 3 years before he ended up hospitalized (I was the mom who complained of coughs that lasted more than normal), the placebo treatment is an insult to parents. Yes, some parents are worry warts who bring in their kid for every sniffle and cough and want ‘treatment,’ but most of us know when something doesn’t seem right and would like to be treated with respect and actual medicine.

    Had a second cough experience…my daughter. Coughed incessantly all day long for weeks. Eventually ended up at an allergist and did x-rays and expensive tests. He actually said to me that he thought it was psychological. She was 7 or 8 at the time. I ignored this ‘advice’ and took her to an ENT who immediately diagnosed her cough as related to our wood stove in the house. After that, she was JUST FINE.

    Anyway, just my unloading on doctors who think they know everything.

  6. What’s this URI business. URTI for the rest of us.

    Coughs alone are not the symptoms that many parents look to treat. Rhinorrhoea and post nasal drip and subsequent productive cough are worrisome for parents.

    If canning cough suppressants like codeine or dextromethorphan, educate readers, just don’t blurt out they are dangerous, which in itself is a bit silly. All drugs are dangerous if used incorrectly.

    Children with URTIs are not isolationist symptoms; parents, unlike many professionals want the whole child to feel better, not just stop a cough.

    Its an uphill battle to educate parents about mangement of respiratory infections. We as health professionals need to so so in a way that empowers parents.

  7. OMG I am TOTALLY going to give the next person in my family to have a cough (whether child or partner) a “dose” of water with a squeeze of lemon juice or something, tell them that it will help with the cough, and see what happens!! … And then I’ll wonder about the extent to which my belief that they will experience a placebo effect has influenced my own perception of any improvement in their condition (if I think I see one). 😉 BTW, the fact that I can expect my kids to be sick once a month all through winter is both reassuring (they’re normal) and depressing (SO sick of snot).

  8. “Not surprisingly, parents of children who were given either placebo or agave nectar reported a significant improvement in the child’s symptoms and in the child’s and parents’ quality of sleep. Well, no duh.”

    That sounds about right, the parents are able to relax and sleep because they believe they have done everything possible to help their child and the child does better because the relaxed parents help break the feedback circle of –>parents worrying about baby –> baby picking up on the worry and reacting negatively –> parents see baby doing worse and worry more.

  9. I think as long as parents are educated as to signs of Tru respiratory distress, then t of t is a good thing. My kids are fans of a spoon of honey, even more so after the study came out, because they are good little science nerds. Both are asthmatic though, and I did get rather irritated with our hmo’s screening for an appointment process when they clearly needed to be seen. Nice post!

  10. Maybe some sort of educational licensing for parenthood would improve the lives of children all around.

    Just a thought. I know the political drawbacks are severe, but still. Getting pregnant is an animal instinct, not a qualifying event for being a good parent. There ought to be some actual training required.

  11. I actually use Vicks vaporub for years if I had a stuffy noseor before bed as sometimes my nose gets stuffy even if I’m not sick. So for me it’s not placebo effect as it does actually clears my nose to breath. But I think that’s from the menthol more then anything else, like walking into a room in which a strong odor is like horseradish

  12. My baby had a terrible cough that turned out to be asthma that went undiagnosed for several months, causing repeated illnesses, sleep problems, and (temporary) developmental delays. It was absolutely dreadful and I wish I had made MORE of a big deal about it to the doctor.

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